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Randomized Controlled Trial
. 2009 Jul 17:4:37.
doi: 10.1186/1749-8090-4-37.

BioGlue and Peri-strips in lung volume reduction surgery: pilot randomised controlled trial

Sridhar Rathinam  1 , Babu V Naidu, Prakash Nanjaiah, Mahmoud Loubani, Maninder S Kalkat, Pala B Rajesh
Affiliations
Randomized Controlled Trial

BioGlue and Peri-strips in lung volume reduction surgery: pilot randomised controlled trial

Sridhar Rathinam et al. J Cardiothorac Surg. .

Abstract

Background: Both tissue sealants and buttressing have been advocated to reduce alveolar air leaks from staple lines following Lung Volume Reduction Surgery (LVRS). However, the long term detrimental effects of buttressing material are increasingly apparent. We performed a pilot prospective randomised self controlled trial in patients undergoing LVRS comparing BioGlue and Peri-strips as adjuncts in preventing alveolar air-leaks.

Methods: A pilot prospective self controlled clinical trial was conducted in patients undergoing LVRS. Each patient was treated with BioGlue on one side and pericardial buttress on the other side as an adjunct to the staple line. The sides were randomised for adjuncts with each patient acting as his own control. Duration of air leak, intercostal drainage and time to chest drain removal were the study end points.

Results: 10 patients undergoing the procedure were recruited between December 2005 and October 2007. There were 6 men and the mean age was 59.8 +/- 4.9 years. There was one mortality due to multi-organ failure. The BioGlue treated side had a shorter mean duration of air-leak (3.0 +/- 4.6 versus 6.5 +/- 6.9 days), lesser chest drainage volume (733 +/- 404 ml versus 1001 +/- 861) and shorter time to chest drain removal (9.7 +/- 10.6 versus 11.5 +/- 11.1 days) compared with Peri-strips.

Conclusion: This study demonstrates comparable efficacy of BioGlue and Peri-strips, however there is a trend favouring the BioGlue treated side in terms of reduction in air-leak, chest drainage volumes, duration of chest drainage and significant absence of complications. A larger sample size is needed to validate this result.

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Figures

Figure 1
Figure 1
Study Protocol.
Figure 2
Figure 2
Comparison of duration of air leak and chest drainage in the two groups. (mean ± standard deviation).
Figure 3
Figure 3
Comparative results of BioGlue and Peri-strips in each patient. The graph represents the number of days with air leak in the BioGlue arm on the left side and Peri-strips arm on the right side and links each patient with a bar. Two patients with identical values are superimposed on one another.
Figure 4
Figure 4
Early cessation of air leak in the BioGlue arm on a day to day basis.
See this image and copyright information in PMC

References

    1. Cooper JD, Trulock EP, Triantafillou AN, Patterson GA, Pohl MS, Deloney PA, Sundaresan RS, Roper CL. Bilateral pneumectomy (volume reduction) for chronic obstructive pulmonary disease. J Thorac Cardiovasc Surg. 1995;109:106–116. doi: 10.1016/S0022-5223(95)70426-4. - DOI - PubMed
    1. Fishman A, Martinez F, Naunheim K, Piantadosi S, Wise R, Ries A, Weinmann G, Wood DE. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med. 2003;348:2059–2073. doi: 10.1056/NEJMoa030287. - DOI - PubMed
    1. DeCamp MM, Blackstone EH, Naunheim KS, Krasna MJ, Wood DE, Meli YM, McKenna RJ., Jr Patient and surgical factors influencing air leak after lung volume reduction surgery: lessons learned from the National Emphysema Treatment Trial. Ann Thorac Surg. 2006;82:197–206. doi: 10.1016/j.athoracsur.2006.02.050. - DOI - PubMed
    1. Geddes D, Davies M, Koyama H, Hansell D, Pastorino U, Pepper J, Agent P, Cullinan P, MacNeill SJ, Goldstraw P. Effect of lung-volume-reduction surgery in patients with severe emphysema. N Engl J Med. 2000;343:239–245. doi: 10.1056/NEJM200007273430402. - DOI - PubMed
    1. Cooper JD. Technique to reduce air leaks after resection of emphysematous lung. Ann Thorac Surg. 1994;57:1038–1039. - PubMed

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