Review
doi: 10.1016/j.jcv.2009.06.017.
Epub 2009 Jul 16.
A perspective on antiviral resistance
Affiliations
- PMID: 19615937
- DOI: 10.1016/j.jcv.2009.06.017
Item in Clipboard
Review
A perspective on antiviral resistance
J Clin Virol.
2009 Sep.
Abstract
More than 25 years after the licensure of aciclovir and then penciclovir, followed by their respective prodrugs valaciclovir and famciclovir, cases of clinically relevant resistance to these drugs in immunocompetent individuals remain very rare. The aim of this review is to focus on the mechanism of action of these anti HSV drugs and then briefly compare this favourable outcome with that of CMV, HIV, HBV and influenza. A central theme is that resistance is an epiphenomenon of failure to suppress virus replication, so that improved potency and selectivity should be prioritised when developing new drugs rather than activity against resistant strains per se.
Similar articles
-
Antiviral resistance and impact on viral replication capacity: evolution of viruses under antiviral pressure occurs in three phases.Handb Exp Pharmacol. 2009;(189):299-320. doi: 10.1007/978-3-540-79086-0_11. Handb Exp Pharmacol. 2009. PMID: 19048205 Review.
-
Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials.Arch Virol. 2003 Sep;148(9):1757-69. doi: 10.1007/s00705-003-0124-7. Arch Virol. 2003. PMID: 14505088 Clinical Trial.
-
Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patients.Clin Infect Dis. 2004 Nov 1;39 Suppl 5:S248-57. doi: 10.1086/422364. Clin Infect Dis. 2004. PMID: 15494896 Review.
-
Antiviral drug resistance.Antiviral Res. 2006 Sep;71(2-3):117-21. doi: 10.1016/j.antiviral.2006.03.004. Epub 2006 Mar 30. Antiviral Res. 2006. PMID: 16621040 Review.
-
Low-abundance drug resistance mutations: extending the HIV paradigm to hepatitis B virus.J Infect Dis. 2009 Dec 1;200(11):1798-9; author reply 1799-1800. doi: 10.1086/647991. J Infect Dis. 2009. PMID: 19905934 No abstract available.
Cited by
-
Targeting the Brain Reservoirs: Toward an HIV Cure.Front Immunol. 2016 Sep 30;7:397. doi: 10.3389/fimmu.2016.00397. eCollection 2016. Front Immunol. 2016. PMID: 27746784 Free PMC article. Review.
-
Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV).Drug Des Devel Ther. 2018 Jul 30;12:2337-2359. doi: 10.2147/DDDT.S171087. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 30104863 Free PMC article.
-
Achieving a cure for HIV infection: do we have reasons to be optimistic?J Antimicrob Chemother. 2012 May;67(5):1063-74. doi: 10.1093/jac/dkr599. Epub 2012 Feb 1. J Antimicrob Chemother. 2012. PMID: 22294645 Free PMC article. Review.
-
The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases.Mar Drugs. 2022 May 28;20(6):363. doi: 10.3390/md20060363. Mar Drugs. 2022. PMID: 35736166 Free PMC article. Review.
-
Anti-HSV activity of serpin antithrombin III.Int Trends Immun. 2014 Apr;2(2):87-92. Int Trends Immun. 2014. PMID: 25215309 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
