Review
doi: 10.1016/j.smim.2009.06.004.
Epub 2009 Jul 17.
The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis
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- PMID: 19616449
- DOI: 10.1016/j.smim.2009.06.004
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Review
The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis
Semin Immunol.
2009 Oct.
Abstract
Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.
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