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Review
. 2009 Oct;21(5):308-12.
doi: 10.1016/j.smim.2009.06.004. Epub 2009 Jul 17.

The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

David Engel  1 , Tom Seijkens, Marjorie Poggi, Maryam Sanati, Larissa Thevissen, Linda Beckers, Erwin Wijnands, Dirk Lievens, Esther Lutgens
Affiliations
Review

The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

David Engel et al. Semin Immunol. 2009 Oct.

Abstract

Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.

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