Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Sep 18;27(41):5685-91.
doi: 10.1016/j.vaccine.2009.06.098. Epub 2009 Jul 17.

Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine

F M Russell  1 , A Balloch, M L K Tang, J R Carapetis, P Licciardi, J Nelson, A W J Jenney, L Tikoduadua, L Waqatakirewa, J Pryor, G B Byrnes, Y B Cheung, E K Mulholland
Affiliations

Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine

F M Russell et al. Vaccine. .

Abstract

The aim was to identify an appropriate infant pneumococcal vaccination strategy for resource poor countries. Fijian infants received zero, one, two, or three doses of 7-valent pneumococcal conjugate vaccine (PCV) in early infancy. Following three PCV doses, geometric mean concentration (GMC) to all seven serotypes were > or = 1.0 microg/mL, and >85% of children achieved antibody levels > or = 0.35 microg/mL at 18 weeks. Following two doses, GMC were lower for 6B, 14, and 23F, but higher for 19F compared with three doses. Following a single dose, significant responses were seen for all serotypes post-primary series compared with the unvaccinated. By 12 months, differences between two and three doses persisted for serotype 14 only. Although GMC following three doses are higher than after two doses, the differences were small. A single dose may offer some protection for most serotypes.

PubMed Disclaimer

Figures

Figure 1
Figure 1
CONSORT chart of the screened and enrolled children to 12 months of age
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. The WHO Young Infants Study Group. Conclusions from the WHO multicenter study of serious infections in young infants. Pediatric Infect Dis J. 1999;18:S32–4. - PubMed
    1. Pneumococcal Conjugate Vaccine for childhood immunization-WHO position paper. World Health Organization Weekly Epidemiological Record No. 12. 2007;82:93–104. - PubMed
    1. Denny FW, Loda FA. Acute respiratory infections are the leading cause of death in children in developing countries. American Journal of Tropical Medicine & Hygiene. 1986;35(1):1–2. - PubMed
    1. Park IH, Pritchard DG, Cartee R, Brandao A, Brandileone MC, Nahm MH. Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae. J Clin Microbiol. 2007;45(4):1225–33. - PMC - PubMed
    1. Hausdorrf WP, Bryant J, Kloek C, Paradiso PR, Siber GR. The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II. CID. 2000;30(1):122–40. - PubMed

Publication types

Substances