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Review
. 2009 Jul 23;6(1):5-9.
doi: 10.1016/j.chom.2009.06.006.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook

Nicolas Legrand  1 , Alexander Ploss, Rudi Balling, Pablo D Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard A Flavell, Carlos A Guzman, Nicholas D Huntington, Dina Kremsdorf, Michael P Manns, Markus G Manz, Jean-Jacques Mention, Michael Ott, Chozhavendan Rathinam, Charles M Rice, Anthony Rongvaux, Sean Stevens, Hergen Spits, Hélène Strick-Marchand, Hitoshi Takizawa, Anja U van Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler
Affiliations
Review

Humanized mice for modeling human infectious disease: challenges, progress, and outlook

Nicolas Legrand et al. Cell Host Microbe. .

Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

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Figures

Figure 1.
Figure 1.. Strategies for the Creation and Optimization of Humanized Mice for the Study of Human Infectious Diseases
The generation of pathogen-specific humanized mouse models is a long-term goal in order to better understand human pathogenesis and to test therapeutic interventions in a preclinical setting. iPS, induced pluripotent stem cells; ES, embryonic stem cells; HSC, hematopoietic stem cells; LADME, liberation, absorption, distribution, metabolism, excretion.
See this image and copyright information in PMC

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