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. 2009 Aug 15;19(16):4639-42.
doi: 10.1016/j.bmcl.2009.06.079. Epub 2009 Jun 25.

Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Christopher J Burns  1 , Michael F Harte, Xianyong Bu, Emmanuelle Fantino, Max Joffe, Harrison Sikanyika, Stephen Su, C Elisabet Tranberg, Neil Wilson, Susan A Charman, David M Shackleford, Andrew F Wilks
Affiliations

Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Christopher J Burns et al. Bioorg Med Chem Lett. .

Abstract

CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported.

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