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. 2009 Sep;191(18):5865-7.
doi: 10.1128/JB.00683-09. Epub 2009 Jul 17.

Region of difference 1 in nontuberculous Mycobacterium species adds a phylogenetic and taxonomical character

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Region of difference 1 in nontuberculous Mycobacterium species adds a phylogenetic and taxonomical character

Jakko van Ingen et al. J Bacteriol. 2009 Sep.

Abstract

The esat-6 and cfp-10 genes are essential for virulence in Mycobacterium tuberculosis. Among nontuberculous mycobacteria, we found these genes only in M. kansasii, M. szulgai, M. marinum, and M. riyadhense, with unique sequences. This adds a phylogenetic and taxonomical characteristic and may represent a virulence factor for nontuberculous mycobacteria.

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Figures

FIG. 1.
FIG. 1.
Phylogenetic trees based on multiple sequence alignment of esat-6 (A), cfp-10 (B), and concatenated esat-6 and cfp-10 (C) sequences. The neighbor-joining tree was created and bootstrapped 1,000× with CLUSTALX and visualized with MEGA 4.0 (13, 14). Bootstrap values are indicated at the nodes.

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