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Clinical Trial
. 2010 Mar;45(3):587-9.
doi: 10.1038/bmt.2009.170. Epub 2009 Jul 20.

Comparison of immune recovery in recipients of unmanipulated vs T-cell-depleted grafts from unrelated donors in a multicenter randomized phase II-III trial (T-cell depletion trial)

C A Keever-Taylor, J E Wagner, N A Kernan, T N Small, S L Carter, J S Thompson, G A Cloud, L S Lamb
Clinical Trial

Comparison of immune recovery in recipients of unmanipulated vs T-cell-depleted grafts from unrelated donors in a multicenter randomized phase II-III trial (T-cell depletion trial)

C A Keever-Taylor et al. Bone Marrow Transplant. 2010 Mar.
No abstract available

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Conflict of interest statement

Conflict of interest

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
T-lymphocyte recovery over 2 years for patients who received unmodified marrow grafts (solid lines and filled circles) vs patients who received grafts depleted of αβ +T cells using T10B9-A1.31 +complement (dashed lines and open triangles) or grafts processed by elutriation (dashed lines and filled squares). Shown are total T cells (CD3), major subsets (CD3 +CD4 +, CD3 +CD8 +, TCR-αβ, TCR-γδ) and naive CD4 + T cells (CD3 +CD4 +CD45RA +). Horizontal lines designate lower normal values. The upper normal range was not exceeded and is omitted to allow more detail for the plots. Mean TCR-αβ and CD3 +CD4 +CD45RA + T-cell counts were consistently higher in the elutriated group but not so significant. Indeed, with the exception of αβ T-cell numbers at 24 months post-BMT, no group showed statistically superior T-cell or T cell subset recovery at any time point.
Figure 2
Figure 2
B-lymphocyte (CD3–CD19 +) and NK cell (CD3–CD56 +) recovery over 2 years for patients who received unmodified marrow grafts (black lines and filled circles) vs patients who received grafts depleted of T cells using T10B9-A1.31 +complement (dashed lines and open triangles) or grafts processed by elutriation (dashed lines and filled squares). Horizontal lines represent the upper and lower normal range. B-cell absolute count reached the lower normal range at ~6 months for both groups and recovery did not differ between groups at any time point post-BMT. The NK cell absolute count was within the normal range at the first measurement period for both groups. NK recovery was significantly more robust in patients who received αβTCD grafts for the initial 12 months post-BMT but did not exceed the upper normal range.
See this image and copyright information in PMC

References

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