doi: 10.1021/np900310j.
Aromatic cyclic peroxides and related keto-compounds from the Plakortis sp. component of a sponge consortium
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- PMID: 19618913
- PMCID: PMC2842915
- DOI: 10.1021/np900310j
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Aromatic cyclic peroxides and related keto-compounds from the Plakortis sp. component of a sponge consortium
J Nat Prod.
2009 Aug.
Abstract
Six unreported aromatic compounds, 1-6, were isolated, along with the known compounds dehydrocurcuphenol and manoalide, from a sample of Plakortis sp., which was the main component of a Pacific sponge consortium. The new molecules were chemically characterized by spectroscopic methods. Compounds 1-4 contain a six-membered cyclic peroxide, whereas 5 and 6 display a terminal methyl ketone. The new metabolites were tested for antifungal and antibacterial properties. Compounds 1 and 4 were weakly active against S. aureus.
Figures
Peroxides 1 and 2 and Ketones 5 and 6 Could Be Derived from Common Intermediates I and II
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