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Review
. 2009 Dec;19(6):394-400.
doi: 10.1016/j.semcancer.2009.07.005. Epub 2009 Jul 18.

EBV and genomic instability--a new look at the role of the virus in the pathogenesis of Burkitt's lymphoma

Bettina Gruhne  1 , Siamak Akbari Kamranvar, Maria G Masucci, Ramakrishna Sompallae
Affiliations
Review

EBV and genomic instability--a new look at the role of the virus in the pathogenesis of Burkitt's lymphoma

Bettina Gruhne et al. Semin Cancer Biol. 2009 Dec.

Abstract

Epidemiological and molecular evidence links Epstein-Barr virus (EBV) carriage to the pathogenesis of human malignancies of lymphoid and epithelial cell origin but the mechanisms of viral oncogenesis are poorly understood. Burkitt's lymphoma, a tumor occurring in both EBV-positive and -negative forms, provides a convenient model for analysis of the relative contribution of genetic changes and viral products that are expressed in the malignant cells. Here we review recent findings that highlight several mechanisms by which EBV could play an important role in oncogenesis by promoting genomic instability.

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