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Meta-Analysis
. 2009 Oct;30(10):1722-8.
doi: 10.1093/carcin/bgp177. Epub 2009 Jul 20.

Human papillomavirus type 16 and 18 in primary lung cancers--a meta-analysis

Malini Srinivasan  1 , Emanuela Taioli, Camille C Ragin
Affiliations
Meta-Analysis

Human papillomavirus type 16 and 18 in primary lung cancers--a meta-analysis

Malini Srinivasan et al. Carcinogenesis. 2009 Oct.

Abstract

Lung cancer is the leading cause of cancer mortality worldwide. A possible carcinogenic role of human papillomavirus (HPV) has been investigated for >20 years and has major clinical and public health implications. We performed a meta-analysis to assess the prevalence of HPV16 and HPV18 in primary lung cancers (2435 subjects from 37 published studies). The overall HPV prevalence ranged from 0.0 to 78.3% with large heterogeneity across geographic regions and histological tissue types. A higher proportion, 50% (7/14), of the European studies reported low or no HPV prevalence (0-10%) compared with the Asian studies, 22% (4/18). When the analysis was limited to HPV16 and HPV18 prevalence, a higher prevalence in Asia (HPV16 = 11.6% and HPV18 = 8.8%) than in Europe (HPV16 = 3.5% and HPV18 = 3.6%) was observed. Studies using HPV-specific primers resulted in higher prevalence rates than consensus HPV primers (HPV16: Asia = 13% and Europe = 6%; HPV18: Asia = 13% and Europe = 5%). Further studies are needed to elucidate the role of HPV in lung carcinogenesis with careful thought given to study design and laboratory detection methods for a more accurate assessment of HPV status in lung tumors.

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Figures

Fig. 1.
Fig. 1.
Comparison of prevalence of HPV16 in (A) Asia and (B) Europe. (▪), study-specific HPV prevalence estimate and horizontal lines represent the study-specific CIs; the sizes of the rectangles depict how each study is weighted in the analysis and is related to the size of the study; (♦), meta-estimate of HPV prevalence and the width of the diamond represent the CI for the meta-estimate. TS, type-specific HPV primers; CS, consensus HPV primers.
Fig. 2.
Fig. 2.
Comparison of prevalence HPV18 in (A) Asia and (B) Europe. (▪), study-specific HPV prevalence estimate and horizontal lines represent the study-specific CIs; the sizes of the rectangles depict how each study is weighted in the analysis and is related to the size of the study; (♦), meta-estimate of HPV prevalence and the width of the diamond represents the CI for the meta-estimate. TS, type-specific HPV primers; CS, consensus HPV primers.
See this image and copyright information in PMC

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