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. 1977 Jul 21;268(5617):208-13.
doi: 10.1038/268208a0.

The location of the polio genome protein in viral RNAs and its implication for RNA synthesis

A Nomoto, B Detjen, R Pozzatti, E Wimmer

The location of the polio genome protein in viral RNAs and its implication for RNA synthesis

A Nomoto et al. Nature. .

Abstract

Evidence is presented that a small protein (VPg) is covalently attached to the 5'-terminal oligonucleotide VPg-pU-U-A-A-A-A-C-A-Gp of the polio genome, to nascent strands of the polio replicative intermediate and to poly(U) of minus strands. A model of polio RNA replication is proposed implicating VPg in initiation of RNA symthesis, possibly as primer.

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