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. 2009 Aug;41(8):873-5.
doi: 10.1038/ng.419. Epub 2009 Jul 20.

Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma

Christine F Skibola  1 , Paige M Bracci, Eran Halperin, Lucia Conde, David W Craig, Luz Agana, Kelly Iyadurai, Nikolaus Becker, Angela Brooks-Wilson, John D Curry, John J Spinelli, Elizabeth A Holly, Jacques Riby, Luoping Zhang, Alexandra Nieters, Martyn T Smith, Kevin M Brown
Affiliations

Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma

Christine F Skibola et al. Nat Genet. 2009 Aug.

Abstract

We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

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Figures

Figure 1
Figure 1. P-values for association testing of SNPs in the 6p21.33 region
(a) −log10 allelic p-values from the individual genotyping of the NC1 and NC2 sample sets. (b) −log10 trend p-values for both individually genotyped (□) and imputed SNPs (x) in the NC1 and NC2 sample sets. (c) Regional recombination rates (centimorgans per Mb) estimated from Phase II HapMap are shown at the bottom.
See this image and copyright information in PMC

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