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. 2009 Sep-Oct;28(5):w770-81.
doi: 10.1377/hlthaff.28.5.w770. Epub 2009 Jul 21.

Broadened use of atypical antipsychotics: safety, effectiveness, and policy challenges

Stephen Crystal  1 , Mark Olfson, Cecilia Huang, Harold Pincus, Tobias Gerhard
Affiliations

Broadened use of atypical antipsychotics: safety, effectiveness, and policy challenges

Stephen Crystal et al. Health Aff (Millwood). 2009 Sep-Oct.

Abstract

Atypical antipsychotic medications are increasingly used for a wide range of clinical indications in diverse populations, including privately and publicly insured youth and elderly nursing home residents. These trends heighten policy challenges for payers, patients, and clinicians related to appropriate prescribing and management, patient safety, and clinical effectiveness. For clinicians and patients, balancing risks and benefits is challenging, given the paucity of effective alternative treatments. For health care systems, regulators, and policymakers, challenges include developing the evidence base on comparative risks and benefits; defining measures of treatment quality; and implementing policies that encourage evidence-based practices while avoiding unduly burdensome restrictions.

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Figures

EXHIBIT 3
EXHIBIT 3
Use Of Antipsychotics Among Privately Insured And Medicaid Youth, 1996–2006 SOURCE: Authors' analyses of data from Medicaid Analytic Extracts (MAX) and Thomson MarketScan (for privately insured youth), based on any antipsychotic prescription in the target year.
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References

    1. See Shekelle P, et al. Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics. [accessed 1 July 2009]. Comparative Effectiveness Review no. 6, January 2007, http://www.effectivehealthcare.ahrq.gov/repFiles/Atypical_ Antipsychotics_Final_Report.pdf..

    1. IMS Health 2007 Top Therapeutic Classes by U.S. Sales. 2008. [accessed 1 July 2009]. http://imshealth.com/imshealth/Global/Content/Document/Top-Line%20Indust....
    1. Esposito D, et al. Trends in Medicaid Prescription Drug Use and Costs, 1999 to 2002: Evidence from Medicaid Analytic Extract Data. AcademyHealth Annual Research Meeting; Washington, D.C.. June 2007.
    2. Centers for Medicare and Medicaid Services Chartbook: Medicaid Pharmaceutical Benefit Use and Reimbursement in 2003. [accessed 1 July 2009]. http://www.cms.hhs.gov/MedicaidDataSourcesGenInfo/downloads/Pharmacy_RX_....

    1. For a description of our data sources, study population, and study methods, see the Methods Appendix, online at http:content.healthaffairs.org/cgi/content/full/hlthaff.28.5.w770/DC2.

    1. Olfson M, et al. National Trends in the Outpatient Treatment of Children and Adolescents with Antipsychotic Drugs. Archives of General Psychiatry. 2006;63(no. 6):679–685. - PubMed

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