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Comment
. 2009 Jul 28;106(30):12217-8.
doi: 10.1073/pnas.0906427106. Epub 2009 Jul 21.

Ku's essential role in keeping telomeres intact

Sandra M Indiviglio  1 , Alison A Bertuch
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Comment

Ku's essential role in keeping telomeres intact

Sandra M Indiviglio et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Possible scenarios by which Ku prevents telomere loss and t-circle formation. (A) Ku inhibits t-loop excision. This might occur (i) directly, independent of other proteins, via regulation of both TRF2 and WRN, or via recruitment of a protein/factor that represses recombination or (ii) indirectly, through free Ku sequestering away from telomeres a protein that promotes t-loop excision. (B) Ku prevents intramolecular recombination between telomeric repeats, independent of t-loops.
See this image and copyright information in PMC

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References

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