Ascorbic acid and the eye
- PMID: 1962570
- DOI: 10.1093/ajcn/54.6.1198s
Ascorbic acid and the eye
Abstract
In this report literature on transport and function of ascorbic acid in ocular tissues is reviewed. The role of ascorbic acid in various regions of the eye is not well understood. It appears one important function of this compound is protection against oxidative damage, particularly photoinduced damage. In contrast, data are also reviewed that suggest ascorbic acid may participate in the oxidative modification of lens proteins seen with aging.
Similar articles
-
Ocular ascorbate transport and metabolism.Comp Biochem Physiol A Comp Physiol. 1991;100(2):273-85. doi: 10.1016/0300-9629(91)90470-w. Comp Biochem Physiol A Comp Physiol. 1991. PMID: 1685949 Review.
-
Ascorbic acid and the eye.Subcell Biochem. 1996;25:313-29. doi: 10.1007/978-1-4613-0325-1_16. Subcell Biochem. 1996. PMID: 8821981 Review. No abstract available.
-
Effect of dietary ascorbic acid on heat-induced eye lens protein damage in guinea pigs.Ophthalmic Res. 1990;22(2):106-10. doi: 10.1159/000267008. Ophthalmic Res. 1990. PMID: 2342780
-
A protective role for ascorbic acid during inflammatory episodes in the eye.Exp Eye Res. 1986 Mar;42(3):211-8. doi: 10.1016/0014-4835(86)90055-2. Exp Eye Res. 1986. PMID: 3709692
-
Increased susceptibility to metal catalysed oxidation of diabetic lens beta L crystallin: possible protection by dietary supplementation with acetylsalicylic acid.Exp Eye Res. 1993 Dec;57(6):783-90. doi: 10.1006/exer.1993.1186. Exp Eye Res. 1993. PMID: 8150030
Cited by
-
Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review).Mol Med Rep. 2025 Jan;31(1):22. doi: 10.3892/mmr.2024.13387. Epub 2024 Nov 8. Mol Med Rep. 2025. PMID: 39513587 Free PMC article. Review.
-
Regulation of tissue oxygen levels in the mammalian lens.J Physiol. 2004 Sep 15;559(Pt 3):883-98. doi: 10.1113/jphysiol.2004.068619. Epub 2004 Jul 22. J Physiol. 2004. PMID: 15272034 Free PMC article.
-
Antioxidant capacity of lenses with age-related cataract.Oxid Med Cell Longev. 2012;2012:467130. doi: 10.1155/2012/467130. Epub 2012 Jan 29. Oxid Med Cell Longev. 2012. PMID: 22363833 Free PMC article.
-
Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract.Br J Ophthalmol. 2019 Sep;103(9):1223-1227. doi: 10.1136/bjophthalmol-2018-312257. Epub 2018 Nov 15. Br J Ophthalmol. 2019. PMID: 30442817 Free PMC article.
-
Functional characterization and molecular identification of vitamin C transporter (SVCT2) in human corneal epithelial (HCEC) and retinal pigment epithelial (D407) cells.Curr Eye Res. 2015 May;40(5):457-69. doi: 10.3109/02713683.2014.935443. Epub 2014 Jul 11. Curr Eye Res. 2015. PMID: 25014399 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical