Cognitive development following pediatric solid organ transplantation

Abstract

Purpose of review: Cognitive development and school function are important psychosocial outcomes that should be monitored closely in children following transplantation. This review includes discussion of a small number of studies published within the past year and details future directions in this area of research.

Recent findings: An analysis of school-aged kidney transplant recipients revealed normal intelligence, but suggested significant impairment in gross motor and fine motor skills. Another study of adults who received kidney transplantation as children revealed that these patients rated their quality of life relatively high despite ongoing medical problems, delayed educational goals and a higher rate of unemployment than the general population. Psychoeducational outcomes of 30 pediatric liver transplant recipients who had onset of chronic liver disease in early infancy revealed that 27% of the group had intelligence scores that were more than 2 standard deviations below test norms. Progress in studying these outcomes in heart and intestinal transplant recipients has been slow and there was no new report published in this time frame.

Summary: There are considerable gaps in our knowledge of these types of outcomes, but current studies support neurocognitive delay as an important problem for children receiving organ transplantation.