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. 2009 Aug;12(3):168-77.
doi: 10.1111/j.1601-6343.2009.01450.x.

Differential gene expression in the perichondrium and cartilage of the neonatal mouse temporomandibular joint

R J Hinton  1 , M Serrano, S So
Affiliations

Differential gene expression in the perichondrium and cartilage of the neonatal mouse temporomandibular joint

R J Hinton et al. Orthod Craniofac Res. 2009 Aug.

Abstract

Our goal was to discover genes differentially expressed in the perichondrium (PC) of the mandibular condylar cartilage (MCC) that might enhance regenerative medicine or orthopaedic therapies directed at the tissues of the temporomandibular joint. We used targeted gene arrays (osteogenesis, stem cell) to identify genes preferentially expressed in the PC and the cartilaginous (C) portions of the MCC in 2-day-old mice. Genes with higher expression in the PC sample related to growth factor ligand-receptor interactions [FGF-13 (6.4x), FGF-18 (4x), NCAM (2x); PGDF receptors, transforming growth factor (TGF)-beta and IGF-1], the Notch isoforms (especially Notch 3 and 4) and their ligands or structural proteins/proteoglycans [collagen XIV (21x), collagen XVIII (4x), decorin (2.5x)]. Genes with higher expression in the C sample consisted mostly of known cartilage-specific genes [aggrecan (11x), procollagens X (33x), XI (14x), IX (4.5x), Sox 9 (4.4x) and Indian hedgehog (6.7x)]. However, the functional or structural roles of several genes that were expressed at higher levels in the PC sample are unclear [myogenic factor (Myf) 9 (9x), tooth-related genes such as tuftelin (2.5x) and dentin sialophosphoprotein (1.6x), VEGF-B (2x) and its receptors (3-4x) and sclerostin (1.7x)]. FGF, Notch and TGF-beta signalling may be important regulators of MCC proliferation and differentiation; the relatively high expression of genes such as Myf6 and VEGF-B and its receptors suggests a degree of unsuspected plasticity in PC cells.

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Figures

Figure 1
Figure 1
Coronal section of embryonic day 18 (E18) mouse mandibular condylar cartilages illustrating perichondrial (PC) and cartilaginous (C) portions of the tissue. Dashed lines delimit tissue removed for the PC sample. AD, articular disc. Hematoxylin and eosin, 20X.
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