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. 2009 Aug;62(8):431-4.
doi: 10.1038/ja.2009.69. Epub 2009 Jul 24.

Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: I. Taxonomy, fermentation, isolation and biological properties

Hiroyuki Yamazaki  1 , Kenichi Nonaka, Rokuro Masuma, Satoshi Omura, Hiroshi Tomoda
Affiliations

Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: I. Taxonomy, fermentation, isolation and biological properties

Hiroyuki Yamazaki et al. J Antibiot (Tokyo). 2009 Aug.

Abstract

The fungal strain FKI-3765-2, identified as Penicillium radicum, was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). Two new compounds, designated xanthoradones A and B, were isolated from the fermentation broth of the producing strain by solvent extraction, octadecyl silyl column chromatography and preparative HPLC. Xanthoradones A and B potentiated imipenem activity against MRSA by decreasing the MIC value of imipenem from 16 microg ml(-1) to 0.060 and 0.030 microg ml(-1), respectively.

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