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Comment
. 2009 Jul;5(7):e1000576.
doi: 10.1371/journal.pgen.1000576. Epub 2009 Jul 24.

PCH'ing together an understanding of crossover control

Drew Thacker  1 , Scott Keeney
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Comment

PCH'ing together an understanding of crossover control

Drew Thacker et al. PLoS Genet. 2009 Jul.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Only a subset of DSBs become crossovers.
Mouse spermatocyte spreads were stained for the chromosomal axial element SYCP3 (red) and either (A) RAD51 (green) or (B) MLH1 (green). DAPI staining is shown in blue. Each DSB gives rise to a chromosome-associated RAD51 complex, whereas MLH1 complexes localize only to sites that will become crossovers. There is an approximate 9-fold excess of DSB-associated foci relative to crossover-associated foci. Arrowheads point to an example of an autosome with two widely separated MLH1 foci, characteristic of crossover interference. (Images courtesy of Ignasi Roig, Molecular Biology Program, Memorial Sloan-Kettering Cancer Center).
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