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. 2009;48(35):6547-51.
doi: 10.1002/anie.200900984.

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu  1 , Ryan Nagao, Angelique Y Louie
Affiliations

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu et al. Angew Chem Int Ed Engl. 2009.
No abstract available

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Figures

Figure 1
Figure 1
Reaction of complex 1 (2.18 × 10−4 M) with NADH in pH 7.0 deionized water.
Figure 2
Figure 2
Fluorescent spectroscopic change during the reaction of complex 1 (1.82 × 10−4M) with NADH (Gd:NADH =1:1) in pH 7.0 deionized water with excitation at 460 nm. Line from top: complex 1 in the dark, mixture of compound 1 and NADH at: 0, 5, 10, 20, and 30 min.
Figure 3
Figure 3
Aqueous solutions of 1 imaged by T1-weighted MRI before (top) and immediately after addition of NADH (bottom) show different brightness. The ratio of GdIII to NADH in each solution is 1:1.
Figure 4
Figure 4
Fluorescent spectroscopic change during the reaction of complex 1 (1.03 × 10−4 M) with NADH (Gd:NADH =1:1) in P388D1.
Figure 5
Figure 5
T1-weighted MRI signal-intensity change for the reaction of complex 1 (0.28 mM) and NADH (Gd:NADH =1:1) in P388D1.
Scheme 1
Scheme 1
Synthesis of spironaphthoxazine-Gd(DO3A) complex 1.
Scheme 2
Scheme 2
The isomerization of complex 1 triggered by NADH and hydrogen peroxide.
See this image and copyright information in PMC

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References

    1. Hoye AT, Davoren JE, Wipf P, Fink MP, Kagan VE. Acc Chem Res. 2008;41:87 – 97. - PubMed
    1. Mankoff DA. J Nucl Med. 2007;48:18N. - PubMed
    2. Mankoff DA. J Nucl Med. 2007;48:21N. - PubMed
    3. Cao QZ, Cai WB, Niu G, He LN, Chen XY. Clin Cancer Res. 2008;14:6137 – 6145. - PubMed
    1. Westbrook C, Roth CK, Talbot J. MRI in Practice. 3. Blackwell; Malden: 2005.
    1. Jacques V, Desreux JF. Top Curr Chem. 2002;221:123–164.
    2. Ramos J, Sirisawad M, Miller R, Naumovski L. Mol Cancer Ther. 2006;5:1176–1182. - PubMed
    3. Hyodo F, Chuang KH, Goloshevsky AG, Sulima A, Griffiths GL, Mitchell JB, Koretsky AP, Krishna MC. J Cereb Blood Flow Metab. 2008;28:1165 – 1174. - PMC - PubMed
    1. Hyodo F, Soule BP, Matsumoto KI, Matusmoto S, Cook JA, Hyodo E, Sowers AL, Krishna MC, Mitchell JB. J Pharm Pharmacol. 2008;60:1049 – 1060. - PMC - PubMed

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