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. 2009;48(35):6547-51.
doi: 10.1002/anie.200900984.

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu  1 , Ryan Nagao, Angelique Y Louie
Affiliations

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu et al. Angew Chem Int Ed Engl. 2009.
No abstract available

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Figures

Figure 1
Figure 1
Reaction of complex 1 (2.18 × 10−4 M) with NADH in pH 7.0 deionized water.
Figure 2
Figure 2
Fluorescent spectroscopic change during the reaction of complex 1 (1.82 × 10−4M) with NADH (Gd:NADH =1:1) in pH 7.0 deionized water with excitation at 460 nm. Line from top: complex 1 in the dark, mixture of compound 1 and NADH at: 0, 5, 10, 20, and 30 min.
Figure 3
Figure 3
Aqueous solutions of 1 imaged by T1-weighted MRI before (top) and immediately after addition of NADH (bottom) show different brightness. The ratio of GdIII to NADH in each solution is 1:1.
Figure 4
Figure 4
Fluorescent spectroscopic change during the reaction of complex 1 (1.03 × 10−4 M) with NADH (Gd:NADH =1:1) in P388D1.
Figure 5
Figure 5
T1-weighted MRI signal-intensity change for the reaction of complex 1 (0.28 mM) and NADH (Gd:NADH =1:1) in P388D1.
Scheme 1
Scheme 1
Synthesis of spironaphthoxazine-Gd(DO3A) complex 1.
Scheme 2
Scheme 2
The isomerization of complex 1 triggered by NADH and hydrogen peroxide.
See this image and copyright information in PMC

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