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Comment
. 2009 Jun;157(4):537-9.
doi: 10.1111/j.1476-5381.2009.00153.x.

Nitroxyl anion--the universal signalling partner of endogenously produced nitric oxide?

William Martin  1
Affiliations
Comment

Nitroxyl anion--the universal signalling partner of endogenously produced nitric oxide?

William Martin. Br J Pharmacol. 2009 Jun.

Abstract

Although it is generally assumed that the primary product of the three isoforms of NO synthase is the nitric oxide radical (NO(*)), growing evidence suggests that the one-electron reduced form of nitrogen monoxide, nitroxyl anion (NO(-)), may be a natural co-product. Thus, evidence from conduit and resistance arteries and nitrergically innervated tissues indicates that NO(-) exerts widespread signalling functions alongside NO(*) in the cardiovascular and autonomic nervous systems, and perhaps beyond. In this issue of the BJP Andrews et al. add to this debate by providing strong evidence that NO(*) and HNO both contribute to the EDRF-mediated component of in mouse (MMA) and rat (RMA) mesenteric resistance arteries.

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References

    1. Andrews KL, Irvine JC, Tare M, Apostolopoulos J, Favaloro JL, Triggle CR, et al. A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries. Br J Pharmacol. 2009;157:540–550. - PMC - PubMed
    1. Chen G, Suzuki H, Weston AH. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br J Pharmacol. 1988;95:1165–1174. - PMC - PubMed
    1. Cohen RA, Plane F, Najibi S, Huk I, Malinski T, Garland CJ. Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery. Proc Natl Acad Sci USA. 1997;94:4193–4198. - PMC - PubMed
    1. Dierks EA, Burstyn JN. Nitric oxide (NO.), the only nitrogen monoxide redox form capable of activating soluble guanylate cyclase. Biochem Pharmacol. 1996;51:1593–1600. - PubMed
    1. Ellis A, Li CG, Rand MJ. Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta. Br J Pharmacol. 2000;129:513–322. - PMC - PubMed