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. 2009 Jul 24:8:29.
doi: 10.1186/1476-511X-8-29.

Lipid profile in oral submucous fibrosis

Ravi Mehrotra  1 , Shruti Pandya, Ajay Kumar Chaudhary, Himanshu Pratap Singh, Ritesh Kumar Jaiswal, Mangal Singh, S C Gupta, Mamta Singh
Affiliations

Lipid profile in oral submucous fibrosis

Ravi Mehrotra et al. Lipids Health Dis. .

Abstract

Background: Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucous fibrosis (OSMF) and studied the correlation between lipid levels with tobacco consumption.

Materials and methods: In this hospital-based study, 65 clinically diagnosed and histopathologically proven patients of OSMF and 42 age and sex matched controls were studied. In these samples serum lipids including: (i) Total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC) (iv) VLDL cholesterol (VLDLC) (v) triglycerides (vi) Apo-A1 (viii) Apo-B and (viii) LPa were analyzed.

Results: A significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls. Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.

Conclusion: The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous conditions.

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Figures

Figure 1
Figure 1
Showing clinical picture (blanching and fibrosis) in oral submucous fibrosis.
Figure 2
Figure 2
Showing Value of Total Cholesterol in patients of OSMF.
Figure 3
Figure 3
Showing Value of LDL in patients of OSMF.
Figure 4
Figure 4
Showing Value of S. triglyceride in patients of OSMF.
Figure 5
Figure 5
Showing Value of HDL in patients of OSMF.
Figure 6
Figure 6
Showing Value of Apo-A1 in patients of OSMF.
Figure 7
Figure 7
Showing Value of Lipoprotein-A in patients of OSMF Bar.
Figure 8
Figure 8
Showing Value of Apo-B in patients of OSMF.
See this image and copyright information in PMC

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