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. 2009 Jul 23;138(2):215-9.
doi: 10.1016/j.cell.2009.07.001.

Stressing out over tRNA cleavage

Debrah M Thompson  1 , Roy Parker
Affiliations
Free article

Stressing out over tRNA cleavage

Debrah M Thompson et al. Cell. .
Free article

Abstract

A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (tRNAs) by ribonucleases that are normally secreted or sequestered. Ribonuclease activation or release is an intriguing new aspect of cellular stress responses, with a potential impact on translation, apoptosis, cancer, and disease progression.

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