Comment
doi: 10.1016/j.cell.2009.07.005.
A new therapeutic target for leukemia comes to the surface
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- PMID: 19632173
- DOI: 10.1016/j.cell.2009.07.005
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Comment
A new therapeutic target for leukemia comes to the surface
Cell.
.
Free article
Abstract
Expression of the cell-surface protein CD47 allows some normal cells to avoid phagocytosis by macrophages. In this issue, Jaiswal et al. (2009) and Majeti et al. (2009) show that elevated CD47 expression by leukemic stem cells inhibits macrophage activity and is an indicator of poor prognosis for patients with acute myeloid leukemia.
Comment on
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CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.Cell. 2009 Jul 23;138(2):271-85. doi: 10.1016/j.cell.2009.05.046. Cell. 2009. PMID: 19632178 Free PMC article.
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CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.Cell. 2009 Jul 23;138(2):286-99. doi: 10.1016/j.cell.2009.05.045. Cell. 2009. PMID: 19632179 Free PMC article.
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