Review
doi: 10.1016/0163-7258(90)90060-f.
Cyclic AMP and mechanisms of vasodilation
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- PMID: 1963221
- DOI: 10.1016/0163-7258(90)90060-f
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Review
Cyclic AMP and mechanisms of vasodilation
Pharmacol Ther.
1990.
Abstract
Cyclic AMP and the mechanism of vasodilation have been reviewed by first discussing the enzymes involved (adenyl cyclase, cyclic nucleotide phosphodiesterases, cyclic AMP-dependent protein kinase) and then agents that increase cAMP in smooth muscle. Two mechanisms of vasodilation are described: (i) effects on contractile proteins; (ii) effects on Ca2+ levels. Evidence for compartments of cAMP is also presented.
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