Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Oct;15(10):577-86.
doi: 10.1093/molehr/gap057. Epub 2009 Jul 24.

The non-human primate model of endometriosis: research and implications for fecundity

A G Braundmeier  1 , A T Fazleabas
Affiliations
Review

The non-human primate model of endometriosis: research and implications for fecundity

A G Braundmeier et al. Mol Hum Reprod. 2009 Oct.

Abstract

The development of an animal model of endometriosis is crucial for the investigation of disease pathogenesis and therapeutic intervention. These models will enhance our ability to evaluate the causes for the subfertility associated with disease and provide a first-line validation of treatment modulators. Currently rodents and non-human primate models have been developed, but each model has their limitations. The aim of this manuscript is to summarize the current findings and theories on the development of endometriosis and disease progression and the effectiveness of therapeutic targets using the experimental induced model of endometriosis in the baboon (Papio anubis).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Gene dysregulation in ectopic and eutopic endometrium in baboons and women with endometriosis. All references can be found within the manuscript. Red denotes upregulated genes, blue denotes downregulated genes. Abbreviations: TNF, tumour necrosis factor; TGF, transforming growth factor; ICAM, intracellular adhesion molecule; IL, interleukin; MMP, matrix metalloproteinase; VEGF, vascular endothelial growth factor; ESR, oestrogen receptor; PGR, progesterone receptor; HSD, hydroxysteroid dehydrogenase; LIF, leukaemia inhibitory factor; FKBP, regulator of progesterone responsiveness; IGFBP, insulin-like binding protein; CYR, cysteine-rich angiogenic inducer; Hic-5, progesterone responsive gene; avb3, integrin avb3.
See this image and copyright information in PMC

References

    1. Abbott JA, Hawe J, Clayton RD, Garry R. The effects and effectiveness of laparoscopic excision of endometriosis: a prospective study with 2–5 year follow-up. Hum Reprod. 2003;18:1922–1927. - PubMed
    1. Absenger Y, Hess-Stumpp H, Kreft B, Kratzschmar J, Haendler B, Schutze N, Regidor PA, Winterhager E. Cyr61, a deregulated gene in endometriosis. Mol Hum Reprod. 2004;10:399–407. - PubMed
    1. Aghajanova L, Velarde M, Giudice LC. The progesterone receptor co-activator Hic-5 is involved in the pathophysiology of endometriosis. Endocrinology. 2009;150:3863–3870. - PMC - PubMed
    1. Arici A, Seli E, Zeyneloglu HB, Senturk LM, Oral E, Olive DL. Interleukin-8 induces proliferation of endometrial stromal cells: a potential autocrine growth factor. J Clin Endocrinol Metab. 1998;83:1201–1205. - PubMed
    1. Attar E, Tokunaga H, Imir G, Yilmaz MB, Redwine D, Putman M, Gurates B, Attar R, Yaegashi N, Hales DB, et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab. 2009;94:623–631. - PMC - PubMed

Publication types