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Comment
. 2009 Sep;8(17):1659-61.
doi: 10.4161/cbt.8.17.9456. Epub 2009 Sep 7.

Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis

Shikha Khatri  1 , David R Plas
Affiliations
Comment

Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis

Shikha Khatri et al. Cancer Biol Ther. 2009 Sep.
No abstract available

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Figures

Figure 1
Figure 1
SLP-2 resides in the mitochondrial intermembrane space, where it interacts with Mfn2, a regulator of mitochondrial fusion, and regulates OPA1, a regulator of cristae junctions in mitochondria (left). SLP-2 expression is associated with increased OPA1 stability which in turn may contribute to cytochrome c retention due to tight junctions of cristae. Carcinogenesis is associated with elevated expression of SLP-2, enhancing cancer cell resistance to chemotherapeutics. SLP-2 inactivation triggers loss of mitochondrial membrane potential and proteolytic processing of OPA1 (right). In combination with mitochondrial stress, inactivation of SLP-2 can trigger apoptosis associated with DRP1 oligomerization and cytochrome c release.
See this image and copyright information in PMC

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