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. 2010 Mar;16(1):39-45.
doi: 10.1007/s12253-009-9185-6. Epub 2009 Jul 25.

Effects of the inhibition of cyclooxygenase-2 on human esophageal cancer cells: inhibition of cell proliferation and induction of apoptosis

Li Zhang  1 , Jun Tu, Zhong-Lin Yu, Yong-Dong Wu, Cai-Min Xu, Shu-Tian Zhang
Affiliations
Free article

Effects of the inhibition of cyclooxygenase-2 on human esophageal cancer cells: inhibition of cell proliferation and induction of apoptosis

Li Zhang et al. Pathol Oncol Res. 2010 Mar.
Free article

Abstract

Cyclooxygenase-2 (COX-2) has been shown to be upregulated in a variety of tumors so that COX-2 may be a potential target in the treatment of cancer. In order to further explore the mechanism, we used RNA interference to study effects of the inhibition of COX-2 on esophageal squamous cell carcinoma (ESCC) lines. Western blot analysis demonstrated that COX-2 expression was significantly reduced in ESCC cells treated with the COX-2-specific siRNA. Furthermore, the COX-2 siRNA treatment inhibited cell proliferation and induced apoptosis in ESCC cells. In addition, the combination treatment of COX-2 siRNA and acidum acetil salicylicum (aspirin) has a synergistic effect. Therefore, this combination has potential as an anticancer therapy for the treatment of ESCC.

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References

    1. Hepatogastroenterology. 2007 Apr-May;54(75):758-60 - PubMed
    1. Dis Esophagus. 2008;21(1):9-14 - PubMed
    1. Dis Esophagus. 2009;22(1):21-31 - PubMed
    1. Scand J Gastroenterol. 2002 Apr;37(4):467-75 - PubMed
    1. Cell. 1990 Jun 1;61(5):759-67 - PubMed

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