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Review
. 2009 Jun;28(6):668-72.

[Roles of Aurora-A in tumorigenesis and prognosis of breast cancer]

[Article in Chinese]
Liang-Ping Xia  1 , Fei-Fei Zhou, Ming-Tian Yang, Qiang Liu
Affiliations
  • PMID: 19635209
Free article
Review

[Roles of Aurora-A in tumorigenesis and prognosis of breast cancer]

[Article in Chinese]
Liang-Ping Xia et al. Ai Zheng. 2009 Jun.
Free article

Abstract

Aurora kinases play key roles in the transition of G2/M phase by regulating functions of centrosomes and microtubules. Overexpression of Aurora-A, a new oncogene, can induce centrosome amplification, aneuploidy and tumor formation. Aurora kinases are closely associated with breast cancer. In this article, we reviewed the mechanisms of Aurora kinases inducing tumorigenesis of breast cancer via interacting with p53 gene, BRCA1 gene, PTEN/PI3K/AKT pathway, gene polymorphism, estrogen, and so on, analyzed the expression of Aurora kinases in breast cancer and its relationship with prognosis.

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