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Review
. 2009 Dec;53(3):422-5.
doi: 10.1016/j.appet.2009.07.018. Epub 2009 Jul 25.

Dopamine/adenosine interactions involved in effort-related aspects of food motivation

John D Salamone  1 , Merce Correa
Affiliations
Review

Dopamine/adenosine interactions involved in effort-related aspects of food motivation

John D Salamone et al. Appetite. 2009 Dec.

Abstract

Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects of food motivation and appetite intact. DA and adenosine receptors interact to regulate effort-related processes. Adenosine A(2A) antagonists can reverse the effects of DA D(2) antagonists on effort-related choice, and intra-accumbens injections of a adenosine A(2A) agonist produce effects that are similar to those produced by accumbens DA depletion or antagonism. These studies have implications for understanding the neurochemical interactions that underlie activational aspects of motivation.

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