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. 2009 Aug;81(2):235-9.

Nonspecific lymphocytic myocarditis in baboons is associated with Trypanosoma cruzi infection

Marcia C R Andrade  1 , Edward J Dick Jr, Rodolfo Guardado-Mendoza, Michaelle L Hohmann, Diana C P Mejido, John L VandeBerg, Cheryl D DiCarlo, Gene B Hubbard
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Nonspecific lymphocytic myocarditis in baboons is associated with Trypanosoma cruzi infection

Marcia C R Andrade et al. Am J Trop Med Hyg. 2009 Aug.

Abstract

Non-specific lymphocytic myocarditis (NLM) is frequently observed in baboons within the endemic range of Trypanosoma cruzi. We sought to determine whether T. cruzi infection is a cause of baboon NLM. We evaluated serial histologic sections of cardiac muscle, blood cultures, immunohistochemistry, serology, polymerase chain reaction, and clinical pathology from 31 baboons with NLM to determine whether T. cruzi infection is associated with NLM. Eleven baboons with no evidence of T. cruzi infection by serology and no NLM were used as controls. Seropositivity for T. cruzi was 45% in baboons with NLM compared with a 2-3% colony prevalence. NLM lesion severity was significantly higher in seropositive than seronegative baboons with NLM. NLM was significantly more common in older baboons. No statistical association between NLM and sex, weight, or clinical pathology was found. These results suggest an association between NLM and T. cruzi infection in the baboon.

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Figures

FIGURE 1
FIGURE 1
Baboon heart. A, Mild NLM (H&E). B, Moderate NLM (H&E). C, T. cruzi myocarditis with ruptured amastigote nest and lymphocytic myocarditis (H&E). D, T. cruzi amastigote nest (immunohistochemistry).
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