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. 2009 Oct;53(10):4495-7.
doi: 10.1128/AAC.00237-09. Epub 2009 Jul 27.

In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus

Shveta Rani Singh  1 , Alfred E Bacon 3rd, David C Young, Kimberly A Couch
Affiliations

In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus

Shveta Rani Singh et al. Antimicrob Agents Chemother. 2009 Oct.

Abstract

Many clinicians are trying unique strategies, including vancomycin and linezolid in combination, for treatment of patients who do not respond to conventional therapy against methicillin (meticillin)-resistant Staphylococcus aureus. In our study, which illustrated in vitro activity only, no synergistic activity was seen when the two agents were combined. Conversely, antagonistic activity occurred in three of five strains when linezolid was added to vancomycin. Our results indicate that vancomycin and linezolid in combination should be avoided.

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Figures

FIG. 1.
FIG. 1.
Panels A through E graphically illustrate the results at two times the MIC for each bacterial strain, comparing the activity of vancomycin and linezolid together against that of each antibiotic alone as well as the results for the control group, which did not contain any antibiotics.
See this image and copyright information in PMC

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