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Editorial
. 2009 Sep;54(3):451-3.
doi: 10.1161/HYPERTENSIONAHA.109.135855. Epub 2009 Jul 27.

Are macrophages the foot soldiers in the war waged by aldosterone against the heart?

Editorial

Are macrophages the foot soldiers in the war waged by aldosterone against the heart?

Anne M Dorrance. Hypertension. 2009 Sep.
No abstract available

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Conflict of interest statement

Disclosures: None

Figures

Figure 1
Figure 1
Macrophage specific deletion of the mineralocorticoid receptor (MR) does not impair adhesion or infiltration in response to deoxycorticosterone (DOC) but does prevent the formation of cardiac fibrosis.

Comment on

References

    1. Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res. 2008;102:1359–1367. - PMC - PubMed
    1. Lombes M, Oblin ME, Gasc JM, Baulieu EE, Farman N, Bonvalet JP. Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res. 1992;71:503–510. - PubMed
    1. Rickard AJ, Morgan J, Tesch G, Funder JW, Fuller PJ, Young MJ. Deletion of mineralocorticoid receptors from macrophages protects against DOC/salt-induced cardiac fibrosis and increased blood pressure. Hypertension. 2009 - PubMed
    1. Young M, Funder J. Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Endocrinology. 2003;144:3848–3851. - PubMed
    1. Young M, Funder JW. Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats. Endocrinology. 2004;145:3153–3157. - PubMed

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