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Review
. 2009 Oct 2;284(40):27025-9.
doi: 10.1074/jbc.R109.040543. Epub 2009 Jul 27.

What is the metabolic role of phosphoenolpyruvate carboxykinase?

Jianqi Yang  1 , Satish C Kalhan, Richard W Hanson
Affiliations
Review

What is the metabolic role of phosphoenolpyruvate carboxykinase?

Jianqi Yang et al. J Biol Chem. .
No abstract available

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Figures

FIGURE 1.
FIGURE 1.
Cataplerosis in action: PEPCK as a feeder reaction for carbon from the citric acid cycle to various biosynthetic and oxidative processes. The entry of selected amino acids into the citric acid cycle and their subsequent disposal via PEPCK-C are shown. The biosynthetic pathways of gluconeogenesis (a), glyceroneogenesis (b), and serine synthesis (c) are outlined, as is the recycling/oxidation of the carbon skeletons of amino acids back into the citric acid cycle (d) as acetyl-CoA for subsequent oxidation or conversion to fatty acids. The metabolic basis for these various routes of disposal of amino acid carbon is discussed in detail in text. OAA, oxalacetate.
FIGURE 2.
FIGURE 2.
Changes in the activity of hepatic PEPCK and the concentration of glycerol in the blood of O. mordax (the rainbow smelt) in response to changes in ocean temperature. This figure has been redrawn from Fig. 4 in a review by Liebscher et al. (19), with the permission of the authors. Some of the data in this figure were derived from the published work of Lewis et al. (20). The activity of hepatic PEPCK is presented as a gray bar graph, the ocean temperature is shown in blue, and the concentration of glycerol in the blood of the rainbow smelt is presented as a red line.
See this image and copyright information in PMC

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