Case Reports
doi: 10.1097/MJT.0b013e3181afbf73.
Brugada electrocardiographic pattern induced by amitriptyline overdose
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- PMID: 19636245
- DOI: 10.1097/MJT.0b013e3181afbf73
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Case Reports
Brugada electrocardiographic pattern induced by amitriptyline overdose
Am J Ther.
2010 Sep-Oct.
Abstract
Tricyclic antidepressants (TCAs) remain a common cause of fatal drug poisoning as a result of their cardiovascular toxicity manifested by electrocardiographic abnormalities, arrhythmias, and hypotension. The principal mechanism of toxicity is cardiac sodium channel blockade. Brugada electrocardiographic pattern (BEP) has also been described in TCA overdose. Currently, very little is known about the relationship between the Brugada syndrome and TCAs. We report the case of a patient who presented with BEP after intake of a high dose of amitriptyline. The patient was treated with continuous sodium bicarbonate infusion leading to resolution of BEP.
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