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Review
. 2009 Sep;10(9):651-7.
doi: 10.1038/nrg2617. Epub 2009 Jul 28.

Systems genetics analysis of cancer susceptibility: from mouse models to humans

David Quigley  1 , Allan Balmain
Affiliations
Review

Systems genetics analysis of cancer susceptibility: from mouse models to humans

David Quigley et al. Nat Rev Genet. 2009 Sep.

Abstract

Genetic studies of cancer susceptibility have shown that most heritable risk cannot be explained by the main effects of common alleles. This may be due to unknown gene-gene or gene-environment interactions and the complex roles of many genes at different stages of cancer. Studies using mouse models of cancer suggest that methods that integrate genetic analysis and genomic networks with knowledge of cancer biology can help to extend our understanding of heritable cancer susceptibility.

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