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Review
. 2009:2009:494928.
doi: 10.1155/2009/494928. Epub 2009 Jul 19.

Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases

Jun-ichi Suzuki  1 , Mitsuaki Isobe, Ryuichi Morishita, Ryozo Nagai
Affiliations
Review

Tea polyphenols regulate key mediators on inflammatory cardiovascular diseases

Jun-ichi Suzuki et al. Mediators Inflamm. 2009.

Abstract

Tea polyphenols known as catechins are key components with many biological functions, including anti-inflammatory, antioxidative, and anticarcinogenic effects. These effects are induced by the suppression of several inflammatory factors including nuclear factor-kappa B (NF-kappaB). While these characteristics of catechins have been well documented, actions of catechins as mediators on inflammation-related cardiovascular diseases have not yet been well investigated. In this article, we reviewed recent papers to reveal the anti-inflammatory effects of catechins in cardiovascular diseases. In our laboratory, we performed oral administration of catechins into murine and rat models of cardiac transplantation, myocarditis, myocardial ischemia, and atherosclerosis to reveal the effects of catechins on the inflammation-induced ventricular and arterial remodeling. From our results, catechins are potent agents for the treatment and prevention of inflammation-related cardiovascular diseases because they are critically involved in the suppression of proinflammatory signaling pathways.

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Figures

Figure 1
Figure 1
Gel mobility shift assay of cardiac transplantation. Gel mobility shift assay documented that increased NF-κκB binding activity was observed in nontreated allografts. This enhanced NF-κB binding was reduced by catechin administration (20 mg/kg/day, THEA-FLAN 90S).
Figure 2
Figure 2
Zymography of myocardial ischemia. Gelatin zymography showed that increased gelatinase (MMP-2 and MMP-9) activity was observed in hearts in the non-treated ischemia group. However, this enhanced gelatinase activity was decreased by catechin administration (20 mg/kg/day, THEA-FLAN 90S).
Figure 3
Figure 3
RNase protection assay of myocarditis. TNF-alpha mRNA level was markedly decreased in the catechin treated group compared with that of control group. On the other hand, mRNA levels of Th2 cytokines such as IL-4 and IL-10 in the catechin treated group (20 mg/kg/day, THEA-FLAN 90S) were markedly enhanced compared with that of control group.
Figure 4
Figure 4
Immunohistochemistry of atherosclerosis. Panels show representative immunohistochemical findings. VCAM-1 expression was enhanced in the aortic walls of non-treated LDLRKO mice. However, catechin administration (2% THEA-FLAN 90S contained high fat chaw) suppressed the expression in the organs of LDLRKO mice.
See this image and copyright information in PMC

References

    1. Mukamal KJ, Maclure M, Muller JE, Sherwood JB, Mittleman MA. Tea consumption and mortality after acute myocardial infarction. Circulation. 2002;105(21):2476–2481. - PubMed
    1. Arts ICW, Hollman PCH, Feskens EJM, Bueno de Mesquita HB, Kromhout D. Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. American Journal of Clinical Nutrition. 2001;74(2):227–232. - PubMed
    1. Kuriyama S, Shimazu T, Ohmori K, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. Journal of the American Medical Association. 2006;296(10):1255–1265. - PubMed
    1. Shimazu T, Kuriyama S, Hozawa A, et al. Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study. International Journal of Epidemiology. 2007;36(3):600–609. - PubMed
    1. Kuriyama S. The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies. Journal of Nutrition. 2008;138(8):1548S–1553S. - PubMed

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