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Clinical Trial
. 2010 Apr;12(2):218-24.
doi: 10.1007/s11307-009-0247-7. Epub 2009 Jul 28.

Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly

Liana G Apostolova  1 , Paul M Thompson, Steve A Rogers, Ivo D Dinov, Charleen Zoumalan, Calen A Steiner, Erin Siu, Amity E Green, Gary W Small, Arthur W Toga, Jeffrey L Cummings, Michael E Phelps, Daniel H Silverman
Affiliations
Clinical Trial

Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly

Liana G Apostolova et al. Mol Imaging Biol. 2010 Apr.

Abstract

Purpose: The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly.

Procedures: Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 +/- 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG)-PET scan (interval 21.7 +/- 3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique.

Results: Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10-15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5-5% similarly distributed decline. ApoE4-positive individuals underwent 5-15% metabolic decline in the posterior association cortices.

Conclusions: Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.

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Figures

Fig. 1
Fig. 1
Statistical maps comparing baseline and follow-up PET data. Several cortical regions including the posterior cingulate, precuneus, lateral temporal, and parietal cortices and left frontal cortex show decline in the uptake of 18F-FDG.
Fig. 2
Fig. 2
Percent difference maps in FDG-PET uptake between baseline and follow-up among cognitively stable (top) and cognitively declining elderly (bottom).
Fig. 3
Fig. 3
Percent difference maps in FDG-PET uptake between baseline and follow-up among ApoE4-negative (top) and ApoE4-positive elderly (bottom).
See this image and copyright information in PMC

References

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