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. 2009 Sep;342(9):507-12.
doi: 10.1002/ardp.200900070.

Synthesis and in-vitro anti-hepatitis-B virus activity of 6H-[1]benzothiopyrano[4,3-b] quinolin-10-ols

Wei Jia  1 , Yanfang Zhao, Rongdong Li, Yanjiao Wu, Zebiao Li, Ping Gong
Affiliations

Synthesis and in-vitro anti-hepatitis-B virus activity of 6H-[1]benzothiopyrano[4,3-b] quinolin-10-ols

Wei Jia et al. Arch Pharm (Weinheim). 2009 Sep.

Abstract

A series of 9-methoxy-6H-[1]benzothiopyrano[4,3-b]quinolin-10-ols with a Mannich side chain were synthesized and evaluated for their anti-Hepatitis B virus (HBV) activity in HepG2.2.15 cells. Some compounds showed significant anti-HBV activity with IC(50) values less than 41 microM. Among them, compound 9b was the most effective anti-HBV agent (IC(50) = 1.7 microM, SI = 60.3).

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