doi: 10.1021/ol901305q.
Palladium-catalyzed sequential cyanation/n-addition/N-arylation in one-pot: efficient synthesis of luotonin A and its derivatives
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- PMID: 19637856
- DOI: 10.1021/ol901305q
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Palladium-catalyzed sequential cyanation/n-addition/N-arylation in one-pot: efficient synthesis of luotonin A and its derivatives
Org Lett.
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Abstract
With the catalysis of palladium, a number of 2-bromo-N-(2-iodobenzyl)benzamides underwent sequential cyanation/N-addition/N-arylation leading to the efficient construction of isoindolo[1,2-b]quinazolin-10(12H)-ones in a two-stage, one-pot manner. This method also allowed the convenient synthesis of luotonin A and its derivatives.
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