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. 2009 Aug 20;11(16):3582-5.
doi: 10.1021/ol901305q.

Palladium-catalyzed sequential cyanation/n-addition/N-arylation in one-pot: efficient synthesis of luotonin A and its derivatives

Yi Ju  1 , Feng Liu, Chaozhong Li
Affiliations

Palladium-catalyzed sequential cyanation/n-addition/N-arylation in one-pot: efficient synthesis of luotonin A and its derivatives

Yi Ju et al. Org Lett. .

Abstract

With the catalysis of palladium, a number of 2-bromo-N-(2-iodobenzyl)benzamides underwent sequential cyanation/N-addition/N-arylation leading to the efficient construction of isoindolo[1,2-b]quinazolin-10(12H)-ones in a two-stage, one-pot manner. This method also allowed the convenient synthesis of luotonin A and its derivatives.

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