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Review
. 2009 Oct;14(19-20):964-72.
doi: 10.1016/j.drudis.2009.07.005. Epub 2009 Jul 26.

Understanding CYP2D6 interactions

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Review

Understanding CYP2D6 interactions

Marcel J de Groot et al. Drug Discov Today. 2009 Oct.

Abstract

Owing to the polymorphic nature of CYP2D6, clinically significant issues can arise when drugs rely on that enzyme either for clearance, or metabolism to an active metabolite. Available screening methods to determine if the compound is likely to cause drug-drug interactions, or is likely to be a victim of inhibition of CYP2D6 by other compounds will be described. Computational models and examples will be given on strategies to design out the CYP2D6 liabilities for both heme-binding compounds and non-heme-binding compounds.

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