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Editorial
. 2009 Aug;32(8):1364-71.
doi: 10.2337/dc09-0113.

Hypoglycemia: from the laboratory to the clinic

Stephanie A Amiel
Editorial

Hypoglycemia: from the laboratory to the clinic

Stephanie A Amiel. Diabetes Care. 2009 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Epinephrine responses to controlled induced hypoglycemia before (△) and after (○) intensification of diabetes control. The hatched area shows the response of a group of healthy individuals who were slightly older than the diabetic subjects. Reprinted with permission from Amiel et al. (14).
Figure 2
Figure 2
Regions of enhanced 18-fluoro-deoxy-glucose uptake during hypoglycemia displayed on magnetic resonance imaging brain slices. A: Relatively greater 18-fluoro-deoxy-glucose uptake in amygdala, cerebellum, and brainstem in people with type 1 diabetes and hypoglycemia awareness than in people with type 1 diabetes and hypoglycemia unawareness, consistent with a greater anxiety and vigilance response in the former. B: Relatively reduced 18-fluoro-deoxy-glucose uptake in the right lateral orbitolfrontal cortex in people with good awareness of hypoglycemia compared with those who are unaware. The reduced activation of this brain region in those with awareness suggested by these data is compatible with the recognition of the unpleasantness or danger of the stimulus encouraging behavior to avoid hypoglycemia in future. This seems to be significantly less effective in those who are unaware. Reprinted with permission from Mason et al. (28).
See this image and copyright information in PMC

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