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Comment
. 2009 Aug;58(8):1728-9.
doi: 10.2337/db09-0749.

Mesenchymal stem cells: a potential border patrol for transplanted islets?

Todd M Brusko  1
Affiliations
Comment

Mesenchymal stem cells: a potential border patrol for transplanted islets?

Todd M Brusko. Diabetes. 2009 Aug.
No abstract available

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Figures

FIG. 1.
FIG. 1.
MSCs protect transplanted allogeneic islets by creating an immunosuppressive microenvironment. MMP-2 and -9 produced by MSCs suppress T-cell responses by cleaving the high-affinity growth factor receptor CD25 (the α-chain of the IL-2 receptor) from the surface of infiltrating T-lymphocytes.
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References

    1. Atkinson MA, Eisenbarth GS: Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001; 358: 221– 229 - PubMed
    1. St Clair EW, Turka LA, Saxon A, et al. : New reagents on the horizon for immune tolerance. Annu Rev Med 2007; 58: 329– 346 - PubMed
    1. Hogan A, Pileggi A, Ricordi C: Transplantation: current developments and future directions: the future of clinical islet transplantation as a cure for diabetes. Front Biosci 2008; 13: 1192– 1205 - PubMed
    1. Ichii H, Ricordi C: Current status of islet cell transplantation. J Hepatobiliary Pancreat Surg 2009; 16: 101– 112 - PMC - PubMed
    1. Fiorina P, Shapiro AM, Ricordi C, et al. : The clinical impact of islet transplantation. Am J Transplant 2008; 8: 1990– 1997 - PubMed

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