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Review
. 2009 Nov;24(11):1409-17.
doi: 10.1177/0883073809338960. Epub 2009 Jul 28.

Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas

Jason Fangusaro  1
Affiliations
Review

Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas

Jason Fangusaro. J Child Neurol. 2009 Nov.

Abstract

Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.

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