[Biochemical markers of bone turnover. New aspect. Bone metabolic markers available in daily practice]
- PMID: 19638690
[Biochemical markers of bone turnover. New aspect. Bone metabolic markers available in daily practice]
Abstract
Changes of bone remodeling markers reflect bone growth and bone turnover. Information on bone metabolism can be attained by blood and urine laboratory tests. Recently developed bone specific markers are categorized by bone remodeling process, i.e. bone formation and resorption. The formation markers include bone-specific alkaline phosphatase (BAP), osteocalcin (OC), undercarboxylated osteocalcin (ucOC), procollagene type I C- and N-terminal peptides (P1CP and P1NP). Bone resorption markers include deoxypyridinoline, collagen I C- and N-terminal telopeptides (CTX and NTX) , and tartrate resistent acid phosphatase (TRACP) isoform 5b. These laboratory tests offer lots of advantages for the diagnosis of bone metabolic disorders and for the evaluation of clinical states of primary osteoporosis and other metabolic skeletal diseases.
Similar articles
-
Markers of bone turnover: biochemical and clinical perspectives.J Endocrinol Invest. 2005;28(10 Suppl):8-13. J Endocrinol Invest. 2005. PMID: 16550716 Review.
-
[Biochemical markers of bone turnover. New aspect. An automated assay for measuring bone turnover markers].Clin Calcium. 2009 Aug;19(8):1160-9. Clin Calcium. 2009. PMID: 19638700 Review. Japanese.
-
Quantification of biochemical markers of bone turnover by kinetic measures of bone formation and resorption in young healthy females.J Bone Miner Res. 1997 Oct;12(10):1714-20. doi: 10.1359/jbmr.1997.12.10.1714. J Bone Miner Res. 1997. PMID: 9333133
-
Collagen-related markers of bone turnover reflect the severity of liver fibrosis in patients with primary biliary cirrhosis.J Bone Miner Res. 1998 Apr;13(4):731-8. doi: 10.1359/jbmr.1998.13.4.731. J Bone Miner Res. 1998. PMID: 9580479
-
[Clinical usefulness of bone turnover markers with the treatment of osteoporosis].Clin Calcium. 2014 Mar;24(3):367-76. Clin Calcium. 2014. PMID: 24576933 Review. Japanese.
Cited by
-
Effect of physical exercise on bone density and remodeling in egyptian type 1 diabetic osteopenic adolescents.Diabetol Metab Syndr. 2011 Sep 30;3:25. doi: 10.1186/1758-5996-3-25. Diabetol Metab Syndr. 2011. PMID: 21961506 Free PMC article.
-
Value of C-telopeptide-cross-linked Type I collagen, osteocalcin, bone-specific alkaline phosphatase and procollagen Type I N-terminal propeptide in the diagnosis and prognosis of bone metastasis in patients with malignant tumors.Med Sci Monit. 2011 Nov;17(11):CR626-633. doi: 10.12659/msm.882047. Med Sci Monit. 2011. PMID: 22037741 Free PMC article.