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Review
. 2009 Aug 18;101(4):551-6.
doi: 10.1038/sj.bjc.6605204. Epub 2009 Jul 28.

Role of miRNAs in the progression of malignant melanoma

D W Mueller  1 , A K Bosserhoff
Affiliations
Review

Role of miRNAs in the progression of malignant melanoma

D W Mueller et al. Br J Cancer. .

Abstract

Analysis of microRNA (miRNA) biogenesis and function is an area of research that started only recently but has subsequently accelerated tremendously. This is because of the impressive impact of miRNA-mediated gene regulation and the obvious potential of those tiny RNA molecules in future diagnostic and therapeutic applications. In this review, recent progress to reveal the role of miRNAs in the tumourigenesis of malignant melanoma, as well as future prospects of melanoma-related miRNA research, will be addressed.

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Figures

Figure 1
Figure 1
Schematic representation of microRNAs (miRNAs) demonstrated to be up- or downregulated during tumourigenesis of malignant melanoma, as described in the paragraph ‘Functional characterisation of single miRNA species in melanoma cells’. miRNAs shown to be deregulated in melanoma progression by a microarray study (Mueller et al, 2009) and subsequently confirmed by qRT–PCR as described in the paragraph ‘A short history about miRNA expression profiling in malignant melanoma’ are indicated by parenthesis.
Figure 2
Figure 2
Overview on microRNAs (miRNAs) with validated target genes and their impact on cellular functions in malignant melanoma as summarised in the paragraph ‘Functional characterisation of single miRNA species in melanoma cells’. The cellular functions indicated are rather related to miRNA than to single confirmed target genes. Those miRNAs indicated by parenthesis in Figure 1 are not included in this diagram, as their target genes as well as their pathophysiological relevance for melanoma have to still be elucidated in detail (VNTR: variable number tandem repeat; Ampl.: amplification, PLZF: promyelocytic leukaemia zinc finger; MITF: microphthalmia-associated transcription factor; CCND1: cyclin D1; ITGB3: integrin beta 3).
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