Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Nov;24(3):218-26.
doi: 10.1016/0147-619x(90)90005-w.

Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331

M E Tolmasky  1
Affiliations
Comparative Study

Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331

M E Tolmasky. Plasmid. 1990 Nov.

Abstract

A fragment of Tn1331 including tnpR, aac, aadA, and a bla gene which encodes lower levels of resistance to ampicillin and carbenicillin as compared to those mediated by the TEM beta-lactamase was sequenced. The polypeptide encoded by the bla gene has homology with the OXA-1, PSE-2, and OXA-2 proteins. Genes aac and bla are upstream and downstream respectively of aadA, and are both flanked by recombinational hot spots. Tn1331 has 520-bp direct repeats which include parts of the tnpR and TEM bla genes. Evolutionary models for the genesis of Tn1331 are proposed.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources